Article
Characterization and analysis of Chinese hamster ovary cell ERCC1 mutant alleles.
Mutagenesis - 1 Jul 1998
Rolig R L, Lowery M P, Adair G M, Nairn R S
Abstract excerpt
We isolated and characterized the ERCC1 coding sequence from three Chinese hamster ovary (CHO) parental (CHO-AA8, CHO-AT3-2 and CHO-9) and 10 ERCC1 mutant cell lines. Two general classes of mutations were observed: two mutant cell lines exhibited nucleotide additions or deletions to produce frameshift mutations and seven mutant cell lines exhibited point mutations that resulted in transitions or transversions,...
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