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Article

Bcr/Abl activates transcription of theBcl-X gene through STAT5

15 Sept 2000

Abstract excerpt

Several tyrosine kinase oncogenes have been associated with myeloproliferative diseases, including Bcr/Abl, Tel/Abl, Tel/Jak2, and Tel/PDGFR. One target molecule shared by these oncogenes is known to be STAT5. We generated sublines of Ba/F3 cells in which either wild-type STAT5 or a constitutively active mutant of STAT5 (STAT5-1*6) were expressed under the control of a tetracycline-inducible promoter. These cell...

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PMID: 10979976
DOI: 10.1182/blood.v96.6.2269

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Bcr/Abl activates transcription of theBcl-X gene through STAT5PMID 10979976Read ↗

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