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Article

Imprinted M6p/Igf2 receptor is mutated in rat liver tumors.

Oncogene - 28 May 1998

Mills J J, Falls J G, De Souza A T, Jirtle R L

Abstract excerpt

We have previously shown that inactivation of mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a common early event in both human liver and breast carcinogenesis. The M6p/Igf2r is imprinted in mice while expression is biallelic in most humans. In this investigation the M6p...

Topics

Animals
Carcinoma, Hepatocellular
DNA, Neoplasm
Genes, Tumor Suppressor
Genomic Imprinting
Liver Neoplasms
Male
Mutation
Rats
Rats, Inbred F344
Rats, Inbred Lew
Receptor, IGF Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9652747
DOI: 10.1038/sj.onc.1201801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9652747-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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