Article
Mutation analysis of the gene encoding the human mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in human cell lines resistant to growth inhibition by transforming growth factor beta(1) (TGF-beta(1)).
Lung cancer (Amsterdam, Netherlands) - 1 Nov 2000
Gemma A, Hosoya Y, Uematsu K, Seike M, Kurimoto F, Yoshimura A, Shibuya M, Kudoh S
Abstract excerpt
The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is involved in activating the transforming growth factor beta(1) (TGF-beta(1)), an inhibitor of the cell proliferation, and limiting the insulin-like growth factor 2 mediated-growth stimulation. The M6P/IGF2R gene has been reported to be mutated and deleted in various cancers, and is a candidate tumor suppressor gene. We studied the genomic...
Topics
- Cell Line
- DNA Mutational Analysis
- DNA Primers
- DNA, Neoplasm
- Drug Resistance, Neoplasm
- Exons
- Genome, Human
- Humans
- Introns
- Mutation