Article
Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality.
Genes & development - 15 Dec 1994
Lau M M, Stewart C E, Liu Z, Bhatt H, Rotwein P, Stewart C L
Abstract excerpt
Murine embryos that inherit a nonfunctional insulin-like growth factor-II/cation-independent mannose 6-phosphate receptor (Igf2r) gene from their fathers are viable and develop normally into adults. However, the majority of mice inheriting the same mutated allele from their mothers die around birth, as a consequence of major cardiac abnormalities. These mice do not express IGF2R in their tissues, are 25-30%...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.