Article
Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality.
Genes & development - 15 Dec 1994
Lau M M, Stewart C E, Liu Z, Bhatt H, Rotwein P, Stewart C L
Abstract excerpt
Murine embryos that inherit a nonfunctional insulin-like growth factor-II/cation-independent mannose 6-phosphate receptor (Igf2r) gene from their fathers are viable and develop normally into adults. However, the majority of mice inheriting the same mutated allele from their mothers die around bir...
Topics
- Alleles
- Animals
- Blood Glucose
- Crosses, Genetic
- Embryonic and Fetal Development
- Exons
- Female
- Fetal Death
- Fetus
- Genomic Imprinting
- Genomic Library
- Heart Defects, Congenital
- Insulin-Like Growth Factor II
- Male
- Mice
- Mice, Inbred C57BL
- Mutagenesis
- Radioimmunoassay