Article
The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix.
Molecular cell - 1 Jun 1998
Ohh M, Yauch R L, Lonergan K M, Whaley J M, Stemmer-Rachamimov A O, Louis D N, Gavin B J, Kley N, Kaelin W G, Iliopoulos O
Abstract excerpt
Fibronectin coimmunoprecipitated with wild-type von Hippel-Lindau protein (pVHL) but not tumor-derived pVHL mutants. Immunofluorescence and biochemical fractionation experiments showed that fibronectin colocalized with a fraction of pVHL associated with the endoplasmic reticulum, and cold competi...
Topics
- Animals
- Cell Line, Transformed
- Embryo, Mammalian
- Extracellular Matrix
- Fibronectins
- Genes, Tumor Suppressor
- Humans
- Ligases
- Mice
- Mice, Mutant Strains
- Mutation
- Protein Binding
- Proteins
- Tumor Cells, Cultured