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Article

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix.

Molecular cell - 1 Jun 1998

Ohh M, Yauch R L, Lonergan K M, Whaley J M, Stemmer-Rachamimov A O, Louis D N, Gavin B J, Kley N, Kaelin W G, Iliopoulos O

Abstract excerpt

Fibronectin coimmunoprecipitated with wild-type von Hippel-Lindau protein (pVHL) but not tumor-derived pVHL mutants. Immunofluorescence and biochemical fractionation experiments showed that fibronectin colocalized with a fraction of pVHL associated with the endoplasmic reticulum, and cold competition experiments suggested that complexes between fibronectin and pVHL exist in intact cells. Assembly of an...

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Source

Identifiers

PMID: 9651579
DOI: 10.1016/s1097-2765(00)80096-9

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix.PMID 9651579Read ↗

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.Semantic proximity Read ↗

[Von-Hippel-Lindau (VHL) protein function by initiation and progression of renal cancer].Semantic proximity Read ↗

Genotype-Phenotype Relations of the von Hippel-Lindau Tumor Suppressor Inferred from a Large-Scale Analysis of Disease Mutations and InteractorsSemantic proximity Read ↗

VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling.Semantic proximity Read ↗

Exploring the role of defective fibronectin matrix assembly in the VHL-associated CNS hemangioblastoma.Semantic proximity Read ↗

Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau gene products is mediated by a 64-amino acid region.Semantic proximity Read ↗

Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function.Semantic proximity Read ↗

Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.Semantic proximity Read ↗

Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein.Semantic proximity Read ↗

The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation.Semantic proximity Read ↗

Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization.Semantic proximity Read ↗

pVHL Modification by NEDD8 Is Required for Fibronectin Matrix Assembly and Suppression of Tumor DevelopmentSemantic proximity Read ↗

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