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Article

The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation.

PLoS genetics - 1 Nov 2020

Chesnel Franck, Couturier Anne, Alusse Adrien, Gagné Jean-Philippe, Poirier Guy G, Jean Dominique, Boisvert François-Michel, Hascoet Pauline, Paillard Luc, Arlot-Bonnemains Yannick, Le Goff Xavier

Abstract excerpt

Loss of von Hippel-Lindau protein pVHL function promotes VHL diseases, including sporadic and inherited clear cell Renal Cell Carcinoma (ccRCC). Mechanisms controlling pVHL function and regulation, including folding and stability, remain elusive. Here, we have identified the conserved cochaperone prefoldin complex in a screen for pVHL interactors. The prefoldin complex delivers non-native proteins to the...

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PMID: 33137104
DOI: 10.1371/journal.pgen.1009183
PMCID: PMC7660911

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