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Article

Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function.

Oncogene - 22 Sept 2016

German P, Bai S, Liu X-D, Sun M, Zhou L, Kalra S, Zhang X, Minelli R, Scott K L, Mills G B, Jonasch E, Ding Z

Abstract excerpt

Loss of von Hippel Lindau (VHL) protein function is a key driver of VHL diseases, including sporadic and inherited clear cell renal cell carcinoma. Modulation of the proteostasis of VHL, especially missense point-mutated VHL, is a promising approach to augmenting VHL levels and function. VHL proteostasis is regulated by multiple mechanisms including folding, chaperone binding, complex formation and...

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Share to Carcinoma, Renal Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26973240
DOI: 10.1038/onc.2016.40
PMCID: PMC5086402

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function.PMID 26973240Read ↗

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