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Article

Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review).

International journal of oncology - 1 Sept 2012

Banno Kouji, Kisu Iori, Yanokura Megumi, Tsuji Kosuke, Masuda Kenta, Ueki Arisa, Kobayashi Yusuke, Yamagami Wataru, Nomura Hiroyuki, Tominaga Eiichiro, Susumu Nobuyuki, Aoki Daisuke

Abstract excerpt

Epimutation is defined as abnormal transcriptional repression of active genes and/or abnormal activation of usually repressed genes caused by errors in epigenetic gene repression. Epimutation arises in somatic cells and the germline, and constitutional epimutation may also occur. Epimutation is t...

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Topics

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Share to Cell Transformation, Neoplastic
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to DNA, Neoplasm

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

Share to Germ-Line Mutation

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 22735547
DOI: 10.3892/ijo.2012.1528
PMCID: PMC3582986

Genes

BRCA1
APC
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22735547-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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