Dedifferentiated chondrocytes cultured in alginate beads: restoration of the differentiated phenotype and of the metabolic responses to interleukin-1beta.

doi:10.1002/(SICI)1097-4652(199808)176:2<303::AID-JCP8>3.0.CO;2-S

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Article

Dedifferentiated chondrocytes cultured in alginate beads: restoration of the differentiated phenotype and of the metabolic responses to interleukin-1beta.

Journal of cellular physiology - 1 Aug 1998

Lemare F, Steimberg N, Le Griel C, Demignot S, Adolphe M

Abstract excerpt

Chondrocytes cultivated in monolayer rapidly divide and lose their morphological and biochemical characteristics, whereas they maintain their phenotype for long periods of time when they are cultivated in alginate beads. Because cartilage has a low cellularity and is difficult to obtain in large...

Topics

Aggrecans
Alcian Blue
Alginates
Animals
Cartilage, Articular
Cell Culture Techniques
Cell Differentiation
Chondrocytes
Chondroitin Sulfate Proteoglycans
Collagen
Coloring Agents
Extracellular Matrix Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression

Immunohistochemistry

Interleukin-1

Lectins, C-Type

Microspheres

Phenotype

Source

Open in PubMed

Identifiers

PMID: 9648917
DOI: 10.1002/(SICI)1097-4652(199808)176:2<303::AID-JCP8>3.0.CO;2-S

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9648917-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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