Re-expression of differentiated proteoglycan phenotype by dedifferentiated human chondrocytes during culture in alginate beads.

doi:10.1016/s0304-4165(98)00105-6

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Article

Re-expression of differentiated proteoglycan phenotype by dedifferentiated human chondrocytes during culture in alginate beads.

Biochimica et biophysica acta - 27 Nov 1998

Liu H, Lee Y W, Dean M F

Abstract excerpt

The proteoglycans (PGs) synthesised by normal human articular chondrocytes and a chondrocyte cell line cultured in monolayer and alginate beads were compared. Chondrocytes became dedifferentiated after serial subcultures in monolayer, exhibited a fibroblastic morphology and synthesised a large pr...

Topics

Alginates
Cell Differentiation
Cell Division
Cell Line
Chondrocytes
Disaccharides
Glycosaminoglycans
Humans
Microspheres
Phenotype
Proteoglycans
Time Factors

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