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Article

Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads.

Osteoarthritis and cartilage - 1 Jul 2004

Gründer Tatiana, Gaissmaier Christoph, Fritz Jürgen, Stoop Reinout, Hortschansky Peter, Mollenhauer Jürgen, Aicher Wilhelm K

Abstract excerpt

OBJECTIVE: For autologous chondrocyte transplantation (ACT) chondrocytes are expanded in vitro. During expansion these cells may dedifferentiate. This change in phenotype is characterized by a raised expression of type I collagen and a decrease in type II collagen expression. Since high expression of type II collagen is of central importance for the properties of hyaline cartilage, we investigated if the growth...

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Identifiers

PMID: 15219571
DOI: 10.1016/j.joca.2004.04.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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