DNA analysis at p53 locus in adenoid cystic carcinoma: comparison of molecular study and p53 immunostaining.

doi:10.1111/j.1440-1827.1998.tb03905.x

Back to search

Article

DNA analysis at p53 locus in adenoid cystic carcinoma: comparison of molecular study and p53 immunostaining.

Pathology international - 1 Apr 1998

Yamamoto Y, Wistuba I I, Kishimoto Y, Virmani A K, Vuitch F, Albores-Saavedra J, Gazdar A F

Abstract excerpt

Abnormalities of the p53 tumor suppressor gene were investigated in 22 foci from 14 adenoid cystic carcinomas (ACC) by polymerase chain reaction (PCR)-based assays for dinucleotide (CA)n and pentanucleotide (AAAAT)n repeat polymorphisms and by immunohistochemical staining for oncoprotein expressi...

Topics

Carcinoma, Adenoid Cystic
DNA, Neoplasm
Genes, p53
Humans
Immunohistochemistry
Loss of Heterozygosity
Mutation
Polymerase Chain Reaction
Tumor Suppressor Protein p53

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.