Article
DNA analysis at p53 locus in adenoid cystic carcinoma: comparison of molecular study and p53 immunostaining.
Pathology international - 1 Apr 1998
Yamamoto Y, Wistuba I I, Kishimoto Y, Virmani A K, Vuitch F, Albores-Saavedra J, Gazdar A F
Abstract excerpt
Abnormalities of the p53 tumor suppressor gene were investigated in 22 foci from 14 adenoid cystic carcinomas (ACC) by polymerase chain reaction (PCR)-based assays for dinucleotide (CA)n and pentanucleotide (AAAAT)n repeat polymorphisms and by immunohistochemical staining for oncoprotein expression. Adenoid cystic carcinomas were divided into lower grade (tubular and cribriform) subtypes and higher grade...
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