Article
Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic carcinoma of the salivary glands.
Human pathology - 1 Nov 1996
Yamamoto Y, Virmani A K, Wistuba I I, McIntire D, Vuitch F, Albores-Saavedra J, Gazdar A F
Abstract excerpt
Adenoid cystic carcinomas (ACC) constitute approximately 20% of malignant salivary gland tumors. Several histological types of ACC are recognized and may coexist in a single tumor. The authors divided ACC into lower grade (tubular and cribriform subtypes) and higher grade (trabecular and solid) subtypes. A preliminary analysis of 10 ACCs showed a relatively high incidence of loss of heterozygosity (LOH) at the...
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