Genetic polymorphisms adjacent to the CAG repeat influence clinical features at onset in Huntington's disease.

doi:10.1136/jnnp.64.6.758

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Article

Genetic polymorphisms adjacent to the CAG repeat influence clinical features at onset in Huntington's disease.

Journal of neurology, neurosurgery, and psychiatry - 1 Jun 1998

Vuillaume I, Vermersch P, Destée A, Petit H, Sablonnière B

Abstract excerpt

OBJECTIVES: To evaluate possible influences of CCG and delta2642 glutamic acid polymorphisms adjacent to the (CAG)n trinucleotide repeat in Huntington's disease gene IT15 on some clinical features (age and symptoms) at onset. METHODS: 84 patients and a control group of 68 unaffected relatives wer...

Topics

Adenine
Adult
Age of Onset
Aged
Alleles
Cytosine
Gene Deletion
Genotype
Guanine
Humans
Huntington Disease
Middle Aged
Phenotype
Point Mutation
Polymorphism, Genetic
Trinucleotide Repeats

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