Article
Linkage disequilibrium between the expanded (CAG)n repeat and an allele of the adjacent (CCG)n repeat in Huntington's disease patients of Greek origin.
European journal of human genetics : EJHG - 1 Jan 1995
Yapijakis C, Vassilopoulos D, Tzagournisakis M, Maris T, Fesdjian C, Papageorgiou C, Plaitakis A
Abstract excerpt
Huntington's disease (HD) is associated with an expanded unstable (CAG)n repeat in the IT15 gene. This repeat was investigated in 44 HD patients and 59 of their relatives at risk who were members of 29 unrelated families from various parts of Greece. Abnormal elongation of the (CAG)n repeat rangi...
Topics
- Age of Onset
- Alleles
- Female
- Greece
- Humans
- Huntington Disease
- Linkage Disequilibrium
- Male
- Pedigree
- Polymorphism, Genetic
- Sex Factors
- Trinucleotide Repeats