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Article

INHIBITORS OF HIV-1 PROTEASE: A Major Success of Structure-Assisted Drug Design

1 Jun 1998

Abstract excerpt

Retroviral protease (PR) from the human immunodeficiency virus type 1 (HIV-1) was identified over a decade ago as a potential target for structure-based drug design. This effort was very successful. Four drugs are already approved, and others are undergoing clinical trials. The techniques utilized in this remarkable example of structure-assisted drug design included crystallography, NMR, computational studies,...

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PMID: 9646869
DOI: 10.1146/annurev.biophys.27.1.249

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