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Rational Approach to AIDS Drug Design Through Structural Biology

1 Feb 2002

Abstract excerpt

The discovery and development of more than a dozen drugs in the past 15 years for the treatment of AIDS offer an excellent example of progress in the field of rational drug design. At this time, the principal targets are reverse transcriptase and protease, enzymes encoded by the human immunodeficiency virus. The introduction of protease inhibitors, in particular, has drastically decreased the mortality and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 11818491
DOI: 10.1146/annurev.med.53.052901.131947

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