Article
Association of asthma and the interleukin-4 promoter gene in Japanese.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Apr 1998
Noguchi E, Shibasaki M, Arinami T, Takeda K, Yokouchi Y, Kawashima T, Yanagi H, Matsui A, Hamaguchi H
Abstract excerpt
BACKGROUND: Susceptibility to the development of asthma and other atopic diseases is known to be associated with genetic components. Several investigator have linked the interleukin-4 (IL-4) gene and nearby markers located on chromosome 5 to atopy and asthma. Recent study has demonstrated that the T allele of a polymorphism in the IL-4 gene promoter region (C-590T) is associated with elevated levels of total...
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