Article
Analysis of beta-thalassemia mutations and beta-locus control region hypersensitive sites 2, 3 and 4 in southern Thailand.
The Southeast Asian journal of tropical medicine and public health - 1 Jan 1997
Sriroongrueng W, Schleiemacher E, Panich V, Nopparatana C, Saechan V, Laosombat V, Pornpatkul M, Fukumaki Y
Abstract excerpt
beta-Thalassemia mutations in 221 chromosomes of unrelated southern Thai patients were analyzed. Using dot blot hybridization of PCR amplified DNA with 15 allele specific oligonucleotide probes for beta-thalassemia mutations 196/221 (89%) of the alleles were characterized. Ten mutations were iden...
Topics
- Alleles
- DNA
- Gene Frequency
- Genotype
- Humans
- Locus Control Region
- Mutation
- Nucleic Acid Hybridization
- Polymerase Chain Reaction
- Thailand
- beta-Thalassemia