Article
The molecular basis of beta-thalassemia in Thailand: application to prenatal diagnosis.
American journal of human genetics - 1 Sept 1990
Thein S L, Winichagoon P, Hesketh C, Best S, Fucharoen S, Wasi P, Weatherall D J
Abstract excerpt
To enable the prenatal diagnosis of beta-thalassemia by direct detection of the mutant beta-globin genes, we have determined the spectrum of mutations causing this disease in Thailand. The techniques employed included a combination of synthetic oligonucleotide probe hybridization, direct sequenci...
Topics
- Base Sequence
- Cloning, Molecular
- Female
- Fetal Diseases
- Genes
- Globins
- Homozygote
- Humans
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Polymerase Chain Reaction
- Pregnancy
- Prenatal Diagnosis
- Thailand
- Thalassemia