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Article

Molecular heterogeneity of beta-thalassaemia in Malaysia: a practical approach to diagnosis.

Annals of the Academy of Medicine, Singapore - 1 Jan 1996

Thong M K, Law H Y, Ng I S

Abstract excerpt

The beta-thalassaemia mutations in 20 Malaysian children with beta-thalassaemia major were characterised by using a multi-modal approach, consisting of a slot-blot hybridisation with selected allele-specific oligonucleotides (ASO), followed by reverse dot-blot assay (RDB), amplification refractory mutation system (ARMS) and genomic sequencing. This strategy yielded a 94.4% mutation detection rate. The 6 most...

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PMID: 8779552

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