Molecular characterization of Hb H disease in southern Thailand.

doi:10.1007/s12185-018-2494-3

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Article

Molecular characterization of Hb H disease in southern Thailand.

International journal of hematology - 1 Oct 2018

Nittayaboon Kesara, Nopparatana Chamnong

Abstract excerpt

Genotypes of 260 individuals with hemoglobin H (Hb H) disease originating from various provinces in southern Thailand were characterized by multiplex PCR (M-PCR) and reverse dot blot hybridization (RDB). M-PCR was used to amplify target fragments and then hybridized with allele-specific oligonucleotide (ASO) probes which were bound on a nylon membrane. A total of eight α-thalassemia (α-thal) mutations, which...

Topics

Genotype
Hemoglobins, Abnormal
Humans
Hydrops Fetalis
Mutation
Prenatal Diagnosis
Sequence Deletion
Thailand
alpha-Thalassemia

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Open in PubMed

Identifiers

PMID: 30006733
DOI: 10.1007/s12185-018-2494-3

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