Article
[Mutation T-->C of nucleotide 2238 in the gene of atrial natriuretic peptide (ANP) precursor and heterogeneity of sodium-sensitive hypertension. Preliminary report].
Polskie Archiwum Medycyny Wewnetrznej - 1 Dec 1997
Ciechanowicz A, Kurzawski G, Widecka K, Goździk J, Adler G, Czekalski S
Abstract excerpt
Atrial natriuretic peptide (ANP) is involved in the pathogenesis of sodium-sensitive hypertension. The loss of Sca I restriction site in the ANP precursor gene abolishes the regular stop codon. The aim of our study was the analysis of the Sca I gene polymorphism in 23 patients with sodium-sensiti...
Topics
- Adult
- Aldosterone
- Atrial Natriuretic Factor
- Base Sequence
- DNA
- Female
- Genotype
- Humans
- Hypertension
- Male
- Nucleotide Mapping
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Renin
- Sodium, Dietary