Article
[Analysis of polymorphisms Sma (Hpa II) and Sca I gene precursors of atrial natriuretic peptide (ANP) in patients with essential hypertension].
Polskie Archiwum Medycyny Wewnetrznej - 1 Jul 1998
Widecka K, Ciechanowicz A, Adler G, Szychot E, Wódecki M, Czekalski S
Abstract excerpt
Both environmental and genetic factors are implicated in the pathogenesis of essential hypertension. The defect of the ANP precursor gene leading to the decrease of ANP synthesis are a cause of the development of sodium-sensitive hypertension in animals. Recent findings in African-Americans who are a model of sodium-sensitive population, reveal a strong association between Sma I polymorphism at intron 2 (the...
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