Article
Attenuation of 6-hydroxydopamine-induced dopaminergic nigrostriatal lesions in superoxide dismutase transgenic mice.
Neuroscience - 1 Aug 1998
Asanuma M, Hirata H, Cadet J L
Abstract excerpt
6-Hydroxydopamine is a neurotoxin that produces degeneration of the nigrostriatal dopaminergic pathway in rodents. Its toxicity is thought to involve the generation of superoxide anion secondary to its autoxidation. To examine the effects of the overexpression of Cu,Zn-superoxide dismutase activi...
Topics
- Animals
- Carrier Proteins
- Corpus Striatum
- Dopamine
- Dopamine Plasma Membrane Transport Proteins
- Functional Laterality
- Iodine Radioisotopes
- Male
- Membrane Glycoproteins
- Membrane Transport Proteins
- Mice
- Mice, Transgenic
- Mutation
- Nerve Tissue Proteins
- Oxidopamine
- Parkinson Disease, Secondary
- Substantia Nigra
- Superoxide Dismutase