Article
Degeneration of dopaminergic neurons in the substantia nigra of zitter mutant rat and protection by chronic intake of Vitamin E.
Neuroscience letters - 3 Jun 2005
Ueda Shuichi, Sakakibara Shin-ichi, Nakadate Kazuhiko, Noda Takahiro, Shinoda Motoo, Joyce Jeffrey N
Abstract excerpt
Dopaminergic cell death in the ventral and dorsal tiers of substantia nigra pars copmacta (SNc) and their prevention by anti-oxidant diet was immunohistochemically studied in the zitter mutant rats, which are characterized by abnormal metabolism of superoxide. Similar to previous reports, the number of SNc neurons in Nissl-stained section decreased with age. Tyrosine hydroxylase (TH) immunohistochemistry...
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