Essential role of caspase-3 in apoptosis of mouse beta-cells transfected with human Fas.

Abstract excerpt

Several recent studies have indicated that the Fas-Fas ligand system may be critical for pancreatic beta-cell destruction in type 1 diabetes. Although the fundamental roles of caspases in the mammalian apoptotic machinery have been elucidated, it is not known which caspase or caspases play a major role in Fas-mediated apoptosis of beta-cells. In this study, we transfected human Fas cDNA into a mouse beta-cell...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Pancreatic function and diabetes