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Gene expression of anti‐ and pro‐apoptotic proteins in malignant and normal plasma cells

12 Jan 2009

Abstract excerpt

The survival of malignant plasma cells is a key event in disease occurrence, progression and chemoresistance. Using DNA-microarrays, we analysed the expression of genes coding for 58 proteins linked with extrinsic and intrinsic apoptotic pathways, caspases and inhibitor of apoptosis proteins. We considered six memory B cells (MBC), seven plasmablasts (PPC), seven bone marrow plasma cells (BMPC) and purified...

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PMID: 19183193
DOI: 10.1111/j.1365-2141.2008.07562.x

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