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Article

Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction.

Development (Cambridge, England) - 1 Jan 1999

Thisse C, Thisse B

Abstract excerpt

Mesoderm induction and patterning are mediated by members of the TGFbeta superfamily. We have isolated a novel zebrafish member, antivin, that structurally is highly related to mouse lefty. Overexpression of antivin completely abolishes mesoderm induction at blastula stage, yet resultant embryos develop well-patterned epidermal and neural derivatives. The mesoderm-inhibiting activity of antivin can be mimicked by...

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Identifiers

PMID: 9847237
DOI: 10.1242/dev.126.2.229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction.PMID 9847237Read ↗

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