Article
Enhancement of strand invasion by oligonucleotides through manipulation of backbone charge.
Nature biotechnology - 1 Dec 1996
Smulevitch S V, Simmons C G, Norton J C, Wise T W, Corey D R
Abstract excerpt
The ability of DNA oligonucleotides, neutral peptide nucleic acids (PNAS), and oligonucleotide conjugates to hybridize to inverted repeat sequences within supercoiled double-stranded DNA by Watson-Crick base-pairing is examined. PNAs and oligonucleotide conjugates initiate and maintain strand invasion under more stringent conditions than do unmodified DNA oligonucleotides. PNAs hybridize rapidly and, once bound,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.