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Article

Terminal sidechain packing of a designed beta-hairpin influences conformation and stability.

Biopolymers - 1 Jul 2009

Eidenschink Lisa, Crabbe Edward, Andersen Niels H

Abstract excerpt

While end capping in alpha-helices is well understood, the concept of capping a beta-hairpin is a relatively recent development; to date, favorable Coulombic interactions are the only example of sidechains at the termini influencing the overall stability of a beta-hairpin. While cross-strand hydrophobic residues generally provide hairpin stabilization, particular when flanking the turn region, those remote from...

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Identifiers

PMID: 19263490
DOI: 10.1002/bip.21177
PMCID: PMC3159043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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