Article
Tonsillar biopsy and PrPSc detection in the preclinical diagnosis of scrapie.
The Veterinary record - 23 May 1998
Schreuder B E, van Keulen L J, Vromans M E, Langeveld J P, Smits M A
Abstract excerpt
Preliminary findings have indicated that in naturally infected sheep, fully susceptible to scrapie (VRQ-homozygous), PrPSc can be detected in the tonsils approximately one year before the expected onset of clinical disease, whereas no immunostaining can be detected in animals with a semi-resistant genotype. This paper describes the technique for taking tonsillar biopsies from sheep and gives the results of the...
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