Article
Association of CYP2D microsatellite polymorphism with Lewy body variant of Alzheimer's disease.
Neurology - 1 Jun 1998
Tanaka S, Chen X, Xia Y, Kang D E, Matoh N, Sundsmo M, Thomas R G, Katzman R, Thal L J, Trojanowski J Q, Saitoh T, Ueda K, Masliah E
Abstract excerpt
OBJECTIVE: To examine the genetic association of CYP2D6 locus with Lewy body variant (LBV) and Parkinson's disease (PD). METHODS: Allelic association was studied in patients with pure AD, LBV, and PD by using the CYP2D microsatellite, the (dG-dT)n dinucleotide repeat (n=16 to 27) located between CYP2D8P and CYP2D7 genes, and the CYP2D6 B and D mutations. RESULTS: We found overrepresentation of the alleles longer...
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