Mutagenic action of 5-nitroimidazoles: in vivo induction of GC-->CG transversion in two Bacteroides fragilis reporter genes.

doi:10.1016/s0027-5107(97)00240-6

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Article

Mutagenic action of 5-nitroimidazoles: in vivo induction of GC-->CG transversion in two Bacteroides fragilis reporter genes.

Mutation research - 26 Feb 1998

Trinh S, Reysset G

Abstract excerpt

The in vivo mutagenic potential of two 5-nitroimidazoles, metronidazole and dimetridazole, was evaluated in Bacteroides fragilis, a strictly anaerobic bacterium. Two antibiotic resistance genes, tetA(Q)3 and nimA, were used as DNA targets. The forward and back mutations were identified by nucleot...

Topics

Amino Acid Sequence
Bacteroides fragilis
Base Sequence
DNA, Bacterial
Genes, Reporter
Molecular Sequence Data
Mutagens
Mutation
Nitroimidazoles
Plasmids
Tetracycline Resistance

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