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Mutagenic action of 5-nitroimidazoles: in vivo induction of GC-->CG transversion in two Bacteroides fragilis reporter genes.

Mutation research - 26 Feb 1998

Trinh S, Reysset G

Abstract excerpt

The in vivo mutagenic potential of two 5-nitroimidazoles, metronidazole and dimetridazole, was evaluated in Bacteroides fragilis, a strictly anaerobic bacterium. Two antibiotic resistance genes, tetA(Q)3 and nimA, were used as DNA targets. The forward and back mutations were identified by nucleotide sequence analysis. Both drugs induced GC-->CG transversion exclusively. The results suggest that the reactive...

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PMID: 9626965
DOI: 10.1016/s0027-5107(97)00240-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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