Article
Mode of action of metronidazole and a Bacteroides fragilis metA resistance gene in Escherichia coli.
The Journal of antimicrobial chemotherapy - 1 Apr 1995
Dachs G U, Abratt V R, Woods D R
Abstract excerpt
The in-vivo mode of action of metronidazole and the MetA protein which confers resistance to metronidazole, was investigated in Escherichia coli wild type and DNA repair-deficient strains. All the E. coli strains were moderately susceptible to metronidazole under aerobic conditions but were more susceptible under anaerobic conditions, and the amount of DNA breakage was less under anaerobic than aerobic...
Topics
- Aerobiosis
- Anaerobiosis
- Bacteroides fragilis
- Culture Media
- DNA Damage
- DNA Repair
- Escherichia coli
- Genes, Bacterial
- Metronidazole
- Microbial Sensitivity Tests
- Mutation