Article
Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects.
The Journal of clinical endocrinology and metabolism - 1 Jun 1998
Panarelli M, Holloway C D, Fraser R, Connell J M, Ingram M C, Anderson N H, Kenyon C J
Abstract excerpt
Genetic variation of the glucocorticoid receptor (GR) locus is associated with differences in blood pressure. To define the intermediate phenotypes associated with this variation, we investigated the biochemical and clinical significance of a BclI restriction fragment length polymorphism of the GR locus in 64 normal male volunteers. Blood samples were genotyped as either AA (homozygous large allele; n = 6), Aa...
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