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Conserved cysteines in Mason-Pfizer monkey virus capsid protein are essential for infectious mature particle formation.

Virology - 1 Aug 2018

Píchalová Růžena, Füzik Tibor, Vokatá Barbora, Rumlová Michaela, Llano Manuel, Dostálková Alžběta, Křížová Ivana, Ruml Tomáš, Ulbrich Pavel

Abstract excerpt

Retrovirus assembly is driven mostly by Gag polyprotein oligomerization, which is mediated by inter and intra protein-protein interactions among its capsid (CA) domains. Mason-Pfizer monkey virus (M-PMV) CA contains three cysteines (C82, C193 and C213), where the latter two are highly conserved among most retroviruses. To determine the importance of these cysteines, we introduced mutations of these residues in...

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PMID: 29906704
DOI: 10.1016/j.virol.2018.06.001
PMCID: PMC6379149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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