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Article

Cysteine residues in the major capsid protein, Vp1, of the JC virus are important for protein stability and oligomer formation.

PloS one - 1 Jan 2013

Kobayashi Shintaro, Suzuki Tadaki, Igarashi Manabu, Orba Yasuko, Ohtake Noriko, Nagakawa Keita, Niikura Kenichi, Kimura Takashi, Kasamatsu Harumi, Sawa Hirofumi

Abstract excerpt

The capsid of the human polyomavirus JC virus (JCV) consists of 72 pentameric capsomeres of a major structural protein, Vp1. The cysteine residues of the related Vp1 of SV40 are known to contribute to Vp1 folding, pentamer formation, pentamer-pentamer contacts, and capsid stabilization. In light of the presence of a slight structural difference between JCV Vp1 and SV40 counterpart, the way the former folds could...

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Identifiers

PMID: 24130786
DOI: 10.1371/journal.pone.0076668
PMCID: PMC3793911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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