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Article

Cysteine residues in the major capsid protein, Vp1, of the JC virus are important for protein stability and oligomer formation.

PloS one - 1 Jan 2013

Kobayashi Shintaro, Suzuki Tadaki, Igarashi Manabu, Orba Yasuko, Ohtake Noriko, Nagakawa Keita, Niikura Kenichi, Kimura Takashi, Kasamatsu Harumi, Sawa Hirofumi

Abstract excerpt

The capsid of the human polyomavirus JC virus (JCV) consists of 72 pentameric capsomeres of a major structural protein, Vp1. The cysteine residues of the related Vp1 of SV40 are known to contribute to Vp1 folding, pentamer formation, pentamer-pentamer contacts, and capsid stabilization. In light...

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Identifiers

PMID: 24130786
DOI: 10.1371/journal.pone.0076668
PMCID: PMC3793911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24130786-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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