Article
Human herpesvirus 8 envelope glycoprotein B mediates cell adhesion via its RGD sequence.
Journal of virology - 1 Mar 2003
Wang Fu-Zhang, Akula Shaw M, Sharma-Walia Neelam, Zeng Ling, Chandran Bala
Abstract excerpt
Human herpesvirus 8 (HHV-8) or Kaposi's sarcoma-associated herpesvirus, implicated in the pathogenesis of Kaposi's sarcoma, utilizes heparan sulfate-like molecules to bind the target cells via its envelope-associated glycoproteins gB and gpK8.1A. HHV-8-gB possesses the Arg-Gly-Asp (RGD) motif, the minimal peptide region of many proteins known to interact with subsets of host cell surface integrins. HHV-8 utilizes...
Topics
- Amino Acid Sequence
- Animals
- CHO Cells
- Cell Adhesion
- Cell Fusion
- Cell Line
- Cricetinae
- Focal Adhesion Kinase 1
- Focal Adhesion Protein-Tyrosine Kinases
- Herpesvirus 8, Human
- Humans
- Molecular Sequence Data
- Mutation
- Oligopeptides