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Article

Human alpha-galactosidase A: glycosylation site 3 is essential for enzyme solubility.

The Biochemical journal - 15 Jun 1998

Ioannou Y A, Zeidner K M, Grace M E, Desnick R J

Abstract excerpt

Human alpha-galactosidase A (EC 3.2.1.22; alpha-Gal A) is the homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. The type, site occupancy and function of the N-linked oligosaccharide chains on this lysosomal hydrolase were determined. Endoglycosidase treatment of the purified recombinant enzyme and mutagenesis studies indicated that three (Asn-139,...

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Identifiers

PMID: 9620884
DOI: 10.1042/bj3320789
PMCID: PMC1219542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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