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Article

Golgi alpha-mannosidase II cleaves two sugars sequentially in the same catalytic site.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 2008

Shah Niket, Kuntz Douglas A, Rose David R

Abstract excerpt

Golgi alpha-mannosidase II (GMII) is a key glycosyl hydrolase in the N-linked glycosylation pathway. It catalyzes the removal of two different mannosyl linkages of GlcNAcMan(5)GlcNAc(2), which is the committed step in complex N-glycan synthesis. Inhibition of this enzyme has shown promise in cert...

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PMID: 18599462
DOI: 10.1073/pnas.0802206105
PMCID: PMC2474516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18599462-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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