Article
Prediction-based threading of the hMSH2 DNA mismatch repair protein.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 1998
de las Alas M M, de Bruin R A, Ten Eyck L, Los G, Howell S B
Abstract excerpt
Mutations in the genes whose products participate in DNA mismatch repair underlie the increased risk of cancer in families with hereditary nonpolyposis colon carcinoma. Mutations in hMSH2 account for approximately 50% of the mutations found in these families. We sought to predict the 3-dimensional structure of hMSH2 by identifying structural homologues using prediction-based threading and by computer modeling...
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