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Article

Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen.

Nature - 29 May 2003

Li Dawei, Zhao Rui, Lilyestrom Wayne, Gai Dahai, Zhang Rongguang, DeCaprio James A, Fanning Ellen, Jochimiak Andrzej, Szakonyi Gerda, Chen Xiaojiang S

Abstract excerpt

The oncoprotein large tumour antigen (LTag) is encoded by the DNA tumour virus simian virus 40. LTag transforms cells and induces tumours in animals by altering the functions of tumour suppressors (including pRB and p53) and other key cellular proteins. LTag is also a molecular machine that disto...

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Share to Adenosine Triphosphate
Share to Amino Acid Motifs
Share to Antigens, Polyomavirus Transforming

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

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Source

Identifiers

PMID: 12774115
DOI: 10.1038/nature01691

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-12774115-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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