Article
Secondary structure prediction and structure-specific sequence analysis of single-stranded DNA.
Nucleic acids research - 1 Aug 2001
Dong F, Allawi H T, Anderson T, Neri B P, Lyamichev V I
Abstract excerpt
DNA sequence analysis by oligonucleotide binding is often affected by interference with the secondary structure of the target DNA. Here we describe an approach that improves DNA secondary structure prediction by combining enzymatic probing of DNA by structure-specific 5'-nucleases with an energy minimization algorithm that utilizes the 5'-nuclease cleavage sites as constraints. The method can identify structural...
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