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Article

CrkII induces serum response factor activation and cellular transformation through its function in Rho activation.

Oncogene - 4 Sept 2003

Iwahara Toshinori, Akagi Tsuyoshi, Shishido Tomoyuki, Hanafusa Hidesaburo

Abstract excerpt

CrkII belongs to the adaptor protein family that plays a crucial role in signal transduction. In order to better understand the biological functions of CrkII, we focused on the regulation of gene expression by CrkII. Various transcriptional control elements were examined for their activation by CrkII-expression, and we found that CrkII selectively activates the serum response element (SRE), a transcriptional...

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Share to GTP-Binding Protein alpha Subunits, G12-G13

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Source

Identifiers

PMID: 12955073
DOI: 10.1038/sj.onc.1206633

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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