Article
Increasing amyloid peptide precursor production and its impact on Alzheimer's disease.
Neurobiology of aging - 1 Jan 2000
Vitek M P
Abstract excerpt
Amyloid peptide precursor (APP) gene expression increases in the brains of patients with Alzheimer's disease (AD). Regulation of expression at the transcriptional and posttranscriptional levels contributes significantly to these increases. Polypeptide hormones stimulate the promoter of the APP gene resulting in increased levels of heterogeneous nuclear RNAs (hnRNA). Through splicing, these hnRNAs are processed...
Topics
- Alzheimer Disease
- Amyloid
- Amyloid beta-Protein Precursor
- Animals
- Drosophila
- Gene Expression Regulation
- Humans
- Mutation
- Protein Precursors