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Article

Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons.

1 Jan 1994

Abstract excerpt

The beta A4-amyloid protein precursor (APP), the source of the beta A4-amyloid deposits found in Alzheimer brains, constitutes a family of transmembrane glycoproteins generated by alternative splicing. While exon 7 and exon 8 are well known to be alternatively spliced, APP mRNA isoforms without exon 15 were only recently identified in leukocytes and rat brain microglial cells and therefore denoted as L-APP mRNAs....

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PMID: 8288617
DOI: 10.1016/s0021-9258(17)42286-1

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