Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma.

Oncogene - 4 Mar 1999

Guldberg P, thor Straten P, Ahrenkiel V, Seremet T, Kirkin A F, Zeuthen J

Abstract excerpt

Mutations in LKB1/STK11, a gene mapping to chromosome 19p13.3 and encoding a widely expressed serine/threonine kinase, were recently identified as the cause of Peutz-Jeghers syndrome. Despite the hamartomatous polyps and increased cancer risk associated with this syndrome, somatic alterations in LKB1/STK11 have not been identified in human tumours. Prompted by another feature of the syndrome, lentigines of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinase Kinases
Share to STK11 gene
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma

Share to Mutation

Share to Peutz-Jeghers Syndrome

Share to Protein Serine-Threonine Kinases

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 10208439
DOI: 10.1038/sj.onc.1202486

Genes

STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma.PMID 10208439Read ↗

Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.Semantic proximity Read ↗

LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma.Semantic proximity Read ↗

Mutations in the human LKB1/STK11 gene.Semantic proximity Read ↗

Two novel mutations and a new STK11/LKB1 gene isoform in Peutz-Jeghers patients.Semantic proximity Read ↗

LKB1 somatic mutations in sporadic tumors.Semantic proximity Read ↗

Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers.Semantic proximity Read ↗

Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families.Semantic proximity Read ↗

STK11/LKB1 germline mutations are not identified in most Peutz-Jeghers syndrome patients.Semantic proximity Read ↗

The molecular basis and clinical aspects of Peutz-Jeghers syndrome.Semantic proximity Read ↗

Analysis of STK11 gene variant in five Chinese patients with Peutz-Jeghers syndrome.Semantic proximity Read ↗

Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.Semantic proximity Read ↗

STK11/LKB1 germline mutations in the first Peutz-Jeghers syndrome patients identified in Slovakia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.