Article
Crystal structures of two mutants that have implications for the folding of bovine pancreatic ribonuclease A.
Protein science : a publication of the Protein Society - 1 May 1998
Pearson M A, Karplus P A, Dodge R W, Laity J H, Scheraga H A
Abstract excerpt
The Tyr92-Pro93 peptide group of bovine pancreatic ribonuclease A (RNase A) exists in the cis conformation in the native state. From unfolding/refolding kinetic studies of the disulfide-intact wild-type protein and of a variant in which Pro93 had been replaced by Ala, it had been suggested that the Tyr92-Ala93 peptide group also exists in the cis conformation in the native state. Here, we report the crystal...
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